Explicit comprehension instruction : a review of research and a new conceptualization of instruction

Includes bibliographical references (p. 13-16)The work upon which this publication was based was supported in part by the Office of Educational Research and Improvement under cooperative agreement no. OEG 0087-C100

Method for culturing mammalian cells in a perfused bioreactor

A bio-reactor system wherein a tubular housing contains an internal circularly disposed set of blade members and a central tubular filter all mounted for rotation about a common horizontal axis and each having independent rotational support and rotational drive mechanisms. The housing, blade members and filter preferably are driven at a constant slow speed for placing a fluid culture medium with discrete microbeads and cell cultures in a discrete spatial suspension in the housing. Replacement fluid medium is symmetrically input and fluid medium is symmetrically output from the housing where the input and the output are part of a loop providing a constant or intermittent flow of fluid medium in a closed loop

Rotating bio-reactor cell culture apparatus

A bioreactor system is described in which a tubular housing contains an internal circularly disposed set of blade members and a central tubular filter all mounted for rotation about a common horizontal axis and each having independent rotational support and rotational drive mechanisms. The housing, blade members and filter preferably are driven at a constant slow speed for placing a fluid culture medium with discrete microbeads and cell cultures in a discrete spatial suspension in the housing. Replacement fluid medium is symmetrically input and fluid medium is symmetrically output from the housing where the input and the output are part of a loop providing a constant or intermittent flow of fluid medium in a closed loop

MHD simulations of the formation and propagation of protostellar jets to observational length scales

We present 2.5-D global, ideal MHD simulations of magnetically and rotationally driven protostellar jets from Keplerian accretion discs, wherein only the initial magnetic field strength at the inner radius of the disc, $B_{\rm i}$, is varied. Using the AMR-MHD code AZEUS, we self-consistently follow the jet evolution into the observational regime ($>10^3\,\mathrm{AU}$) with a spatial dynamic range of $\sim6.5\times10^5$. The simulations reveal a three-component outflow: 1) A hot, dense, super-fast and highly magnetised 'jet core'; 2) a cold, rarefied, trans-fast and highly magnetised 'sheath' surrounding the jet core and extending to a tangential discontinuity; and 3) a warm, dense, trans-slow and weakly magnetised shocked ambient medium entrained by the advancing bow shock. The simulations reveal power-law relationships between $B_{\rm i}$ and the jet advance speed, $v_{\rm jet}$, the average jet rotation speed, $\langle v_\varphi\rangle$, as well as fluxes of mass, momentum, and kinetic energy. Quantities that do not depend on $B_{\rm i}$ include the plasma-$\beta$ of the transported material which, in all cases, seems to asymptote to order unity. Jets are launched by a combination of the 'magnetic tower' and 'bead-on-a-wire' mechanisms, with the former accounting for most of the jet acceleration---even for strong fields---and continuing well beyond the fast magnetosonic point. At no time does the leading bow shock leave the domain and, as such, these simulations generate large-scale jets that reproduce many of the observed properties of protostellar jets including their characteristic speeds and transported fluxes.Comment: 26 pages, 16 figures. Accepted for publication in MNRA

Cell proliferation and differentiation kinetics during spermatogenesis in Hydra carnea

Spermatogenesis inHydra carnea was investigated. The cell proliferation and differentiation kinetics of intermediates in the spermatogenesis pathway were determined, using quantitative determinations of cell abundance, pulse and continuous labelling with3H-thymidine and nuclear DNA measurements. Testes develop in the ectoderm of male hydra as a result of interstitial cell proliferation. Gonial stem cells and proliferating spermatogonia have cell cycles of 28 h and 22 h, respectively. Stem cells undergo four, five or six cell divisions prior to meiosis which includes a premeiotic S+G2 phase of 20 h followed by a long meiotic prophase (22 h). Spermatid differentiation requires 12–29 h. When they first appear, testes contain only proliferating spermatogonia; meiotic and postmeiotic cells appear after 2 and 3 days, respectively and release of mature sperm begins after 4 days. Mature testes produce about 27,000 sperm per day over a period of 4–6 days: about 220 gonial stem cells per testis are required to support this level of sperm differentiation. Further results indicate that somatic (e.g. nematocyte) differentiation does not occur in testes although it continues normally in ectodermal tissue outside testes. Our results support the hypothesis that spermatogenesis is controlled locally in regions of the ectoderm where testes develop

Mind-reading versus neuromarketing: how does a product make an impact on the consumer?

Purpose – This research study aims to illustrate the mapping of each consumer’s mental processes in a market-relevant context. This paper shows how such maps deliver operational insights that cannot be gained by physical methods such as brain imaging. Design/methodology/approach – A marketed conceptual attribute and a sensed material characteristic of a popular product were varied across presentations in a common use. The relative acceptability of each proposition was rated together with analytical descriptors. The mental interaction that determined each consumer’s preferences was calculated from the individual’s performance at discriminating each viewed sample from a personal norm. These personal cognitive characteristics were aggregated into maps of demand in the market for subpanels who bought these for the senses or for the attribute. Findings – Each of 18 hypothesized mental processes dominated acceptance in at least a few individuals among both sensory and conceptual purchasers. Consumers using their own descriptive vocabulary processed the factors in appeal of the product more centrally. The sensory and conceptual factors tested were most often processed separately, but a minority of consumers treated them as identical. The personal ideal points used in the integration of information showed that consumers wished for extremes of the marketed concept that are technologically challenging or even impossible. None of this evidence could be obtained from brain imaging, casting in question its usefulness in marketing. Research limitations/implications – Panel mapping of multiple discriminations from a personal norm fills three major gaps in consumer marketing research. First, preference scores are related to major influences on choices and their cognitive interactions in the mind. Second, the calculations are completed on the individual’s data and the cognitive parameters of each consumer’s behavior are aggregated – never the raw scores. Third, discrimination scaling puts marketed symbolic attributes and sensed material characteristics on the same footing, hence measuring their causal interactions for the first time. Practical implications – Neuromarketing is an unworkable proposition because brain imaging does not distinguish qualitative differences in behavior. Preference tests are operationally effective when designed and analyzed to relate behavioral scores to major influences from market concepts and sensory qualities in interaction. The particular interactions measured in the reported study relate to the major market for healthy eating. Originality/value – This is the first study to measure mental interactions among determinants of preference, as well as including both a marketed concept and a sensed characteristic. Such an approach could be of great value to consumer marketing, both defensively and creatively

Characterizing heterogeneous dynamics at hydrated electrode surfaces

In models of Pt 111 and Pt 100 surfaces in water, motions of molecules in the first hydration layer are spatially and temporally correlated. To interpret these collective motions, we apply quantitative measures of dynamic heterogeneity that are standard tools for considering glassy systems. Specifically, we carry out an analysis in terms of mobility fields and distributions of persistence times and exchange times. In so doing, we show that dynamics in these systems is facilitated by transient disorder in frustrated two-dimensional hydrogen bonding networks. The frustration is the result of unfavorable geometry imposed by strong metal-water bonding. The geometry depends upon the structure of the underlying metal surface. Dynamic heterogeneity of water on the Pt 111 surface is therefore qualitatively different than that for water on the Pt 100 surface. In both cases, statistics of this adlayer dynamic heterogeneity responds asymmetrically to applied voltage.Comment: 6 page, 4 figure

Dyon Spectrum in Generic N=4 Supersymmetric Z_N Orbifolds

We find the exact spectrum of a class of quarter BPS dyons in a generic N=4 supersymmetric Z_N orbifold of type IIA string theory on K3\times T^2 or T^6. We also find the asymptotic expansion of the statistical entropy to first non-leading order in inverse power of charges and show that it agrees with the entropy of a black hole carrying same set of charges after taking into account the effect of the four derivative Gauss-Bonnet term in the effective action of the theory.Comment: LaTeX file, 39 pages; minor change